Publications

2020

Meier-Menches S.M., Neuditschko B., Zappe K., Schaier M., Gerner M.C., Schmetterer K.G., Del Favero G., Bonsignore R., Cichna-Markl M., Koellensperger G., Casini A., Gerner Ch., An Organometallic Gold(I) Bis-N-Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells, Chemistry, 2020 Dec 1;26(67):15528-15537. doi: 10.1002/chem.202003495

Del Favero G., Bonifacio A., Rowland T. J., Gao Sh., Song K., Sergo V., Adler E. D., Mestroni L., Sbaizero O., Taylor M. R. G., Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes, Journal of Clinical Medicine, 2020 Jul 31;9(8):E2457. doi: 10.3390/jcm90824

Hohenbichler J., Aichinger G., Rychlik M., Del Favero G., Marko D., Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro, Biomolecules 2020, 10(7), 1018, July 9, 2020, DOI: 10.3390/biom10071018

Juère E., Del Favero G., Masse F., Marko D., Popat A., Florek J., Caillard R., Kleitz F., Gastro-protective protein-silica nanoparticles formulation for oral drug delivery: in vitro release, cytotoxicity and mitochondrial activity, European Journal of Pharmaceutics and Biopharmaceutics, 2020 June. pii: S0939-6411(20)30082-5. doi: 10.1016/j.ejpb.2020.03.015

Aichinger G., Dellafiora L., Pantazi F., Del Favero G., Galaverna G., Dall'Asta C., Marko D., Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study, Archives of Toxicology, 2020 June, doi: 10.1007/s00204-020-02746-x

Gerner M.C., Ziegler L.S., Schmidt R.L.J., Krenn M., Zimprich F., Uyanik-Ünal K., Konstantopoulou V., Derdak S., Del Favero G., Schwarzinger I., Boztug K., Schmetterer K.G., The TGF-b/SOX4 axis and ROS-driven autophagy co-mediate CD39 expression in regulatory T-cells, FASEB Journal, 2020 June, doi: 10.1096/fj.201902664

Del Favero G., Kraegeloh A., Integrating Biophysics in Toxicology, Cells, 2020 May 21;9(5):E1282. doi: 10.3390/cells9051282

Juère E., Caillard R., Marko D., Del Favero G., Kleitz F., Smart protein-based formulation of dendritic mesoporous silica nanoparticles: Toward oral delivery of insulin, Chemistry, 2020 Apr. 21. doi: 10.1002/chem.202000773

Aichinger G., Lichtenberger F.B., Steinhauer T.N., Flörkemeier I., Del Favero G., Clement B., Marko D., The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties, Molecules. 2020 Mar 27;25(7). pii: E1524. doi: 10.3390/molecules25071524.

Del Favero G., Mayer R.M., Dellafiora L., Janker L., Niederstaetter L., Dall'Asta C., Gerner C., Marko D., Structural Similarity with Cholesterol Reveals Crucial Insights into Mechanisms Sustaining the Immunomodulatory Activity of the Mycotoxin Alternariol, Cells, 2020 Mar 31;9(4). pii: E847. doi: 10.3390/cells9040847

Beisl J., Pahlke G., Abeln H., Ehling-Schulz M., Del Favero G., Varga E., Warth B., Sulyok M., Abia W., Ezekiel CN., Marko D., Combinatory effects of cereulide and deoxynivalenol on in vitro cell viability and inflammation of human Caco-2 cells, Archives of Toxicology, 2020 March, doi: 10.1007/s00204-020-02658-w

Neuditschko B., Janker L., Niederstaetter L., Brunmair J., Krivanek K., Izraely S., Sagi-Assif O., Meshel T., Keppler B., Del Favero G., Witz I.P., Gerner C., The challenge of classifying metastatic cell properties by molecular profiling exemplified with cutaneous melanoma cells and their cerebral metastasis from patient derived mouse xenografts, Molecular & Cellular Proteomics, March 2020, pii: mcp.RA119.001886. doi: 10.1074/mcp.RA119.001886

Muqaku B., Pils D., Mader J.C., Aust S., Mangold A., Muqaku L., Slany A., Del Favero G., Gerner Ch., Neutrophil extracellular trap formation correlates with improved overall survival in ovarian cancer, Cancers (Basel), 2020 Feb 21;12(2). pii: E505. doi: 10.3390/cancers12020505.

Del Favero G., Hohenbichler J., Mayer R.M., Rychlik M., Marko D., Mycotoxin Altertoxin II Induces Lipid Peroxidation Connecting Mitochondrial Stress Response to NF-κB Inhibition in THP-1 Macrophages, Chemical Research in Toxicology, 2020 Feb, doi: 10.1021/acs.chemrestox.9b00378

2019

Costa J.G., Vidovic B., Saraiva N., do Céu Costa M., Del Favero G., Marko D., Oliveira N.G., Fernandes A.S., Contaminants: a dark side of food supplements? Free Radical Research, 2019 Sep 10:1-23. doi: 10.1080/10715762.2019.1636045

Del Favero, G.; Bialas, F.; Grabher-Wusche, S.; Wittig, A.; Bräuer, B.; Gerthsen, D.; Echalier, C.; Kamalov, M.; Marko, D.; Becker, Ch.F.W.; Silica particles with a Quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus, Chemical Communications, Aug, 2019, DOI: 10.1039/C9CC02215E

Gerner, M.C.; Niederstaetter, L.; Ziegler, L.; Bileck, A.; Slany, A.; Janker, L.; Schmidt, R.L.J.; Gerner, Ch.; Del Favero, G.; Schmetterer, K.G.; Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells, frontiers in pharmacology, July 10 2019, doi.org/10.3389/fphar.2019.00727

Wernitznig, D.; Kiakos, K.; Del Favero, G.; Harrer, N.; Machat, H.; Osswald, A.; Jakupec, M. A.; Wernitznig, A.; Sommergruber, W.; Keppler, B. K., First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro. Metallomics. 2019 Jun 19;11(6):1044-1048. doi: 10.1039/c9mt00051h.

Puntscher, H.; Hankele, S.; Tillmann, K.; Attakpah, E.; Braun, D.; Kutt, M. L.; Del Favero, G.; Aichinger, G.; Pahlke, G.; Hoger, H.; Marko, D.; Warth, B., First insights into Alternaria multi-toxin in vivo metabolism. Toxicology letters 2019 Feb;301:168-178. doi: 10.1016/j.toxlet.2018.10.006.

 

2018

Del Favero, G.; Zaharescu, R.; Marko, D., Functional impairment triggered by altertoxin II (ATXII) in intestinal cells in vitro: cross-talk between cytotoxicity and mechanotransduction. Archives of toxicology, Dec. 2018, doi:10.1007/s00204-018-2317-6 (2018).

Woelflingseder, L.; Del Favero, G.; Blazevic, T.; Heiss, E. H.; Haider, M.; Warth, B.; Adam, G.; Marko, D., Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells. Toxicology letters, Dec. 2018,  doi:10.1016/j.toxlet.2018.09.007 (2018).

Del Favero, G.; Woelflingseder, L.; Braun, D.; Puntscher, H.; Kutt, M. L.; Dellafiora, L.; Warth, B.; Pahlke, G.; Dall'Asta, C.; Adam, G.; Marko, D., Response of intestinal HT-29 cells to the trichothecene mycotoxin deoxynivalenol and its sulfated conjugates. Toxicology letters, Oct. 2018, 295, 424-437. doi:10.1016/j.toxlet.2018.07.007.

Miklosi, A. G.; Del Favero, G.; Marko, D.; Harkany, T.; Lubec, G., Resolution Matters: Correlating Quantitative Proteomics and Nanoscale-Precision Microscopy for Reconstructing Synapse Identity. Proteomics, Jul 2018, 18 (14), e1800139 doi:10.1002/pmic.201800139.

Del Favero, G.; Woelflingseder, L.; Janker, L.; Neuditschko, B.; Seriani, S.; Gallina, P.; Sbaizero, O.; Gerner, C.; Marko, D., Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation. Scientific reports, Jul 27, 2018, 8 (1), 11351. doi:10.1038/s41598-018-29728-5.

Miklosi, A. G.; Del Favero, G.; Bulat, T.; Hoger, H.; Shigemoto, R.; Marko, D.; Lubec, G., Super-resolution Microscopical Localization of Dopamine Receptors 1 and 2 in Rat Hippocampal Synaptosomes. Molecular neurobiology, Jun 2018, 55 (6), 4857-4869. doi:10.1007/s12035-017-0688-y.

Dellafiora, L.; Warth, B.; Schmidt, V.; Del Favero, G.; Mikula, H.; Frohlich, J.; Marko, D., An integrated in silico/in vitro approach to assess the xenoestrogenic potential of Alternaria mycotoxins and metabolites. Food chemistry, May 2018, 248, 253-261. doi:10.1016/j.foodchem.2017.12.013.

 

2017

Wittig, A.; Gehrke, H.; Del Favero, G.; Fritz, E. M.; Al-Rawi, M.; Diabate, S.; Weiss, C.; Sami, H.; Ogris, M.; Marko, D., Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells. Nanomaterials (Basel, Switzerland), Jan 2017, 7 (1). doi:10.3390/nano7010018.

Jarolim, K.; Del Favero, G.; Ellmer, D.; Stark, T. D.; Hofmann, T.; Sulyok, M.; Humpf, H. U.; Marko, D., Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase. Archives of toxicology, Apr 2017, 91 (4), 2007-2016. doi:10.1007/s00204-016-1855-z.

Jarolim, K.; Del Favero, G.; Pahlke, G.; Dostal, V.; Zimmermann, K.; Heiss, E.; Ellmer, D.; Stark, T. D.; Hofmann, T.; Marko, D., Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II. Archives of toxicology, Jan 2017, 91 (1), 203-216. doi:10.1007/s00204-016-1726-7.

 

2016

Warth, B.; Del Favero, G.; Wiesenberger, G.; Puntscher, H.; Woelflingseder, L.; Fruhmann, P.; Sarkanj, B.; Krska, R.; Schuhmacher, R.; Adam, G.; Marko, D., Identification of a novel human deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells. Scientific reports, Sept 2016, 6, 33854. doi:10.1038/srep33854.

Seriani, S.; Del Favero, G.; Mahaffey, J.; Marko, D.; Gallina, P.; Long, C. S.; Mestroni, L.; Sbaizero, O., The cell-stretcher: A novel device for the mechanical stimulation of cell populations. The Review of scientific instruments, Aug 2016, 87 (8), 084301. doi:10.1063/1.4959884.

 

2015

Lanzicher, T.; Martinelli, V.; Puzzi, L.; Del Favero, G.; Codan, B.; Long, C. S.; Mestroni, L.; Taylor, M. R.; Sbaizero, O., The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Scientific reports 2015, 5, 13388. doi:10.1038/srep13388.

Schroeter, A.; Groh, I. A.; Del Favero, G.; Pignitter, M.; Schueller, K.; Somoza, V.; Marko, D., Inhibition of topoisomerase II by phase II metabolites of resveratrol in human colon cancer cells. Molecular nutrition & food research 2015, 59 (12), 2448-59. doi:10.1002/mnfr.201500352.

Perkin, J.; Slater, R.; Del Favero, G.; Lanzicher, T.; Hidalgo, C.; Anderson, B.; Smith, J. E.; Sbaizero, O.; Labeit, S.; Granzier, H., Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIdelta Lowers the Single Molecule and Cardiac Muscle Force. Biophysical journal 2015, 109 (12), 2592-601. doi:10.1016/j.bpj.2015.11.002.

Lanzicher, T.; Martinelli, V.; Long, C. S.; Del Favero, G.; Puzzi, L.; Borelli, M.; Mestroni, L.; Taylor, M. R.; Sbaizero, O., AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus (Austin, Tex.) 2015, 6 (5), 394-407. doi:10.1080/19491034.2015.1084453.

Sbaizero, O.; DelFavero, G.; Martinelli, V.; Long, C. S.; Mestroni, L., Analysis of long- and short-range contribution to adhesion work in cardiac fibroblasts: an atomic force microscopy study. Materials science & engineering. C, Materials for biological applications 2015, 49, 217-224. doi:10.1016/j.msec.2014.12.083.

Seriani, S.; Del Favero, G.; Martinelli, V.; Mestroni, L.; Long, C.; Sbaizero, O.; Gallina, P., Quantification of Dual Reporter Cell Cultures via Image Analysis. 2015; Vol. 4, p 350-367.

 

2014

Del Favero, G., S. Sosa, M. Poli, A. Tubaro, O. Sbaizero, and P. Lorenzon. 2014. In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: structural and functional impairmentToxicol Lett 225 (2):285-93. doi: 10.1016/j.toxlet.2013.12.020.

Codan, B., G. Del Favero, V. Martinelli, C. S. Long, L. Mestroni, and O. Sbaizero. 2014. Exploring the elasticity and adhesion behavior of cardiac fibroblasts by atomic force microscopy indentation. Mater Sci Eng C Mater Biol Appl 40:427-34. doi: 10.1016/j.msec.2014.04.003.

 

2009-2013

Del Favero, G., D. Beltramo, M. Sciancalepore, P. Lorenzon, T. Coslovich, M. Poli, E. Testai, S. Sosa, and A. Tubaro. 2013. "Toxicity of palytoxin after repeated oral exposure in mice and in vitro effects on cardiomyocytes."  Toxicon 75:3-15. doi: 10.1016/j.toxicon.2013.06.003.

Del Favero, G., S. Sosa, M. Pelin, E. D'Orlando, C. Florio, P. Lorenzon, M. Poli, and A. Tubaro. 2012. "Sanitary problems related to the presence of Ostreopsis spp. in the Mediterranean Sea: a multidisciplinary scientific approach."  Ann Ist Super Sanita 48 (4):407-14. doi: Doi: 10.4415/ann_12_04_08.

Del Favero, G., C. Florio, B. Codan, S. Sosa, M. Poli, O. Sbaizero, J. Molgo, A. Tubaro, and P. Lorenzon. 2012. "The stretch-activated channel blocker Gd(3+) reduces palytoxin toxicity in primary cultures of skeletal muscle cells."  Chem Res Toxicol 25 (9):1912-20. doi: 10.1021/tx300203x.

Tubaro, A., G. Del Favero, D. Beltramo, M. Ardizzone, M. Forino, M. De Bortoli, M. Pelin, M. Poli, G. Bignami, P. Ciminiello, and S. Sosa. 2011. "Acute oral toxicity in mice of a new palytoxin analog: 42-hydroxy-palytoxin."  Toxicon 57 (5):755-63. doi: 10.1016/j.toxicon.2011.02.009.

Tubaro, A., P. Durando, G. Del Favero, F. Ansaldi, G. Icardi, J. R. Deeds, and S. Sosa. 2011. "Case definitions for human poisonings postulated to palytoxins exposure."  Toxicon 57 (3):478-95. doi: 10.1016/j.toxicon.2011.01.005.

Baumgartner, L., S. Sosa, A. G. Atanasov, A. Bodensieck, N. Fakhrudin, J. Bauer, G. Del Favero, C. Ponti, E. H. Heiss, S. Schwaiger, A. Ladurner, U. Widowitz, R. D. Loggia, J. M. Rollinger, O. Werz, R. Bauer, V. M. Dirsch, A. Tubaro, and H. Stuppner. 2011. "Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro."  J Nat Prod 74 (8):1779-86. doi: 10.1021/np200343t.

Giangaspero, A., C. Ponti, F. Pollastro, G. Del Favero, R. Della Loggia, A. Tubaro, G. Appendino, and S. Sosa. 2009. "Topical anti-inflammatory activity of Eupatilin, a lipophilic flavonoid from mountain wormwood ( Artemisia umbelliformis Lam.)."  J Agric Food Chem 57 (17):7726-30. doi: 10.1021/jf901725p.

Sosa, S., G. Del Favero, M. De Bortoli, F. Vita, M. R. Soranzo, D. Beltramo, M. Ardizzone, and A. Tubaro. 2009. "Palytoxin toxicity after acute oral administration in mice."  Toxicol Lett 191 (2-3):253-9. doi: 10.1016/j.toxlet.2009.09.009.